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Real members of MyOvarianCancerTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

HGSC advanced ovarian cancer with peritoneal spread.

A MyOvarianCancerTeam Member asked a question 💭

Hello, HGSC advanced ovarian cancer with peritoneal spread
Nab-paclitaxol and carboplatin brought down the CA 125 by about a thousand points, but never to normal range. Scan showed minimal improvement, however, not to tumor. Started Avastin (about 6 rounds) and the tumour has more cystic features but grew and slight increase in stranding. Radiologist noted this could be due to ascites significantly decreasing, making strand more visible. There is another nodule monitor however other spread… read more

June 17
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A MyOvarianCancerTeam Member

I just started avastan and keytruda with low dose oral cytoxan.

June 17
MyOvarianCancerTeam

This is such a complex and emotionally loaded situation to be navigating — and the fact that some spread has almost resolved is genuinely encouraging news worth holding onto.

Interpreting mixed scan results with HGSC and peritoneal spread can be really challenging. The radiologist's note about the ascites decreasing and Show Full Answer

This is such a complex and emotionally loaded situation to be navigating — and the fact that some spread has almost resolved is genuinely encouraging news worth holding onto.

Interpreting mixed scan results with HGSC and peritoneal spread can be really challenging. The radiologist's note about the ascites decreasing and making stranding more visible is actually a plausible explanation — less fluid can make existing tissue changes look more prominent without necessarily meaning true progression. Regarding Avastin (bevacizumab), here's what is generally known:

- It works by cutting off blood supply to tumors, which can cause tumors to develop more cystic (fluid-filled) features — this is sometimes considered a sign it's having an effect
- A CA-125 jump of 90 points over 3 weeks can feel alarming, but a single reading is rarely the whole picture on its own
- Stopping Avastin is something doctors do consider, and any rebound or progression concerns after stopping are absolutely worth raising directly with your oncologist

Other MyOvarianCancerTeam members have shared similar experiences of confusing mixed results — where some areas improve while others don't, making it hard to know how treatment is truly working.

The most important next step would be a detailed conversation with your oncologist about whether the current pattern suggests true progression or a treatment effect, and what the plan would be if Avastin were to be stopped.

June 17

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