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A MyOvarianCancerTeam Member asked a question 💭
La Habra, CA

Stage 3c HGSC, BRCA 1, had 3 rounds of chemo before hysterectomy and 4 rounds after.Latest ct scan showed 2 small lesions in stomach, biopsy came back positive for cancer.

February 28
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MyOvarianCancerTeam

Has anyone experienced a recurrence while on Lynparza before completing one year of treatment, and what treatment options were offered?

It's understandably concerning to face a recurrence while on maintenance therapy. While Lynparza significantly reduces the risk of recurrence, breakthrough cancer can still occur, even in Show Full Answer

Has anyone experienced a recurrence while on Lynparza before completing one year of treatment, and what treatment options were offered?

It's understandably concerning to face a recurrence while on maintenance therapy. While Lynparza significantly reduces the risk of recurrence, breakthrough cancer can still occur, even in people with BRCA1 mutations who typically respond well to PARP inhibitors.

For recurrent ovarian cancer, treatment options depend on several factors:

* How long it's been since your last platinum-based chemotherapy
* Whether your cancer is considered platinum-sensitive (recurrence after 6+ months) or platinum-resistant (recurrence within 6 months)
* Your previous treatment responses and side effects
* How much the cancer has spread

Since you're experiencing recurrence relatively soon after initial treatment, your oncologist will likely discuss:

* A different chemotherapy regimen, which might include drugs like paclitaxel, pegylated liposomal doxorubicin, gemcitabine, or topotecan
* Possible debulking surgery to remove the lesions if feasible
* Another targeted therapy option
* Clinical trial participation, which could provide access to newer treatment combinations

A MyOvarianCancerTeam member shared that when facing recurrence, researching clinical trials gave them a sense of control and productive focus during a difficult time.

Your BRCA1 status means you may still have good treatment options available. It's important to have an open conversation with your oncology team about the best path forward for your specific situation.

February 28
A MyOvarianCancerTeam Member

Did physicians mention IVF to prevent the BRCA gene mutation being passed on to a new generation?

June 4
A MyOvarianCancerTeam Member

Unfortunately, I also have BRCA1 from my mother. I'm 28 years old. I'm still not sure if I want more children, so the specialist recommended I get an MRI every year and a mammogram every six months until I feel ready to make a decision.

June 4
A MyOvarianCancerTeam Member

I’m also BRCA 1. Unfortunately, I passed on to my daughter the BRCA mutation. Two sons negative and one son who hasn’t tested positive.

June 3
A MyOvarianCancerTeam Member

Very similar to my mom's. She had 3C HGNC BRCA1 three rounds of chemotherapy, surgery, and another three rounds of chemotherapy. Then she started Lynparza. Ten months after her last chemotherapy, the cancer returned even though she was taking Lynparza. Now we're waiting for a biopsy because the oncologist wants to see if the cancer mutated.

June 3

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