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A MyOvarianCancerTeam Member asked a question 💭
Minneapolis, MN

I was diagnosed with low-grade serous ovarian cancer in January. Since then I have had two surgeries and six chemotherapy infusions. I am now taking the hormone Letrozole, and have been experiencing increasing fatigue. This is not something I have ever had before. Is there another hormone that your doctors have recommended that doesn't have this side effect?

August 30
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MyOvarianCancerTeam

What hormone alternatives to Letrozole have doctors recommended for low-grade serous ovarian cancer that may cause less fatigue?

First, it's worth acknowledging how much you've been through — two surgeries and six chemo infusions is a lot, and fatigue at this stage is incredibly common. It can be hard to know whether the Show Full Answer

What hormone alternatives to Letrozole have doctors recommended for low-grade serous ovarian cancer that may cause less fatigue?

First, it's worth acknowledging how much you've been through — two surgeries and six chemo infusions is a lot, and fatigue at this stage is incredibly common. It can be hard to know whether the fatigue is from Letrozole specifically or the cumulative toll of treatment overall.

Fatigue is a known side effect of hormone therapies used in ovarian cancer treatment. Some strategies that may help manage it include:

- Getting regular physical activity, even light movement
- Spreading activities throughout the day with rest breaks
- Maintaining a balanced diet and staying hydrated
- Asking your doctor to check for iron deficiencies or anemia
- Trying acupuncture — a MyOvarianCancerTeam member noted it helped their fatigue significantly As for switching hormones, that's a very important conversation to have directly with your oncologist. They'll know which alternatives are appropriate for low-grade serous ovarian cancer specifically and can weigh the benefits against side effects for your individual situation.

Don't hesitate to be open with your care team about how the fatigue is affecting your quality of life — that matters and they may have options to help.

August 30

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