I have never use them so I don’t know what do. I am sorry couldn’t answer your question

I have had avastin. It works well but has nose bleeds and for me in a dry climate burning sensation and huge scabs. I just read something yesterday from a member that with Ketruda, you need certain gene mutations (not inherited). If you have them it seems to work well. I have no idea about the combination. I do not know what cyclophosphamide is.