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Real members of MyOvarianCancerTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

CA125

A MyOvarianCancerTeam Member asked a question 💭
Santa Maria, CA

I'm not the one going through this. It's my mom. She was diagnosed in February 2025 with high grade serous carcinoma stage 3c. She had three chemotherapies surgery and then another three chemotherapy. In August 2025 she was already in remission and since she is BRCA1 positive she is taking lynparza. Everything was going well in December 2025 she had a ct and there was no trace of illness but every month they are doing blood tests. In February her CA125 was 8.9 and the CA125 blood test for this… read more

May 11
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MyOvarianCancerTeam

First, it's completely understandable to feel worried — that's a significant jump in CA-125 levels, and your concern for your mom makes total sense. It's clear how much you love her.

To give some context, a CA-125 level below 35–46 units per milliliter is generally considered normal. Your mom's level rising from 8.9 to 403.3 Show Full Answer

First, it's completely understandable to feel worried — that's a significant jump in CA-125 levels, and your concern for your mom makes total sense. It's clear how much you love her.

To give some context, a CA-125 level below 35–46 units per milliliter is generally considered normal. Your mom's level rising from 8.9 to 403.3 is a notable increase and something her medical team will take very seriously. Here's what's important to understand about a rising CA-125:

- A rising CA-125 after remission can be an early signal that cancer may be returning
- It does not confirm recurrence on its own — further testing is needed
- Her oncologist will likely recommend imaging, such as a CT or MRI scan, to get a clearer picture
- A single elevated result always needs to be interpreted alongside symptoms, imaging, and her full medical history

The fact that her team is monitoring her monthly means this has been caught early, which matters a great deal. The most important next step is for her oncologist to be contacted as soon as possible — if they haven't already been in touch — to discuss this result and arrange further testing. Her BRCA1 status and current Lynparza treatment will also factor into any decisions about next steps.

Please try to take this one step at a time. A number on a blood test is the beginning of a conversation with her doctors, not the end of the story.

May 11

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